Harvick led 44 laps Saturday to claim his first victory driving a car he owns. Carl Edwards finished second and Clint Bowyer was third.
Matt Kenseth was fourth after stepping in for teammate Greg Biffle, who pulled out of the race because of bruised ribs. Justin Allgaier was fifth and Busch sixth.
Busch led a race-high 157 laps, but his crew let a tire slide away during the final pit stop. The penalty dropped Busch to 14th on the final restart with 41 laps left.
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Tyson Ross lost his bid to pitch the first no-hitter in San Diego Padres' history when center fielder Franchy Cordero appeared to misplay a ball with two outs in the eighth inning Friday night of a 4-1 win over the Arizona Diamondbacks.