SAN FRANCISCO (AP) - Edgar Renteria hit a grand slam off Jake Peavy and matched his career high with five RBIs, leading the San Francisco Giants to an 8-3 victory over the San Diego Padres on Tuesday night.
Renteria connected in the fourth for his first homer with the Giants, who have won three of four. It was his seventh career grand slam and the first allowed by Peavy in his seven-year career.
Peavy, who struck out 10 and came within two outs of a complete game in a 6-3 win over the Giants on April 11, allowed six runs and seven hits in six innings.
Matt Cain beat San Diego for the first time since 2006 and improved to 2-0 for the first time in his career. The right-hander, who didn't get his first win last year until April 23, scattered nine hits over six innings, yielding just two runs.
Renteria was batting just .200 through the first two weeks, leading to some early criticism for the shortstop's $18.5 million, two-year deal with the Giants in the offseason.
But Renteria added to his history of success with Peavy, collecting three more hits off the San Diego ace to raise his career average to .455 against right-hander.
He scored the Giants' first run on a double-play grounder in the third then hit the first pitch he saw from Peavy in the fourth deep into the left-field stands to make it 5-2. The home run was just the sixth of the season for the Giants, lowest in the NL and second-fewest in the majors behind Oakland.
Peavy (2-2), the 2007 NL Cy Young Award winner, took a step backward after two solid starts and couldn't recover after Renteria's grand slam.
It was the first grand slam allowed by Peavy in 1,284 1-3 innings, the second-longest active streak in the majors, according to Elias Sports Bureau. Houston Astros right-hander Brian Moehler has the longest active streak with 1,360 innings.
Brian Giles singled in a run in the first and Kevin Kouzmanoff added an RBI double in the fourth to give San Diego a 2-1 lead. Chase Headley tried to score on Kouzmanoff's hit and was tagged out at the plate by Bengie Molina.
Renteria also singled in Travis Ishikawa in the sixth, giving him five RBIs in a game for the eighth time in his career.
Ishikawa had two hits, two RBIs and scored twice for San Francisco.
Notes:@ The eight runs are the second-most scored this season by San Francisco, which went into the game as the second-lowest scoring team in the majors behind Houston. The Giants had scored only six runs in their previous four games. ... San Diego acquired utility INF Chris Burke from Seattle only a few weeks after the Mariners acquired Burke from the Padres. Seattle received cash for returning Burke to San Diego. ... Padres SS Everth Cabrera underwent surgery to repair the broken bone on his left hand and is expected to be out six to eight weeks. Cabrera will wear a splint for five days and begin therapy next week. ... Boxer Manny Pacquiao threw out the ceremonial first pitch as part of the Giants' Filipino-American Heritage celebration. Pacquiao is scheduled to fight Ricky Hatton for Hatton's IBO junior welterweight title in Las Vegas on May 2.