The man was driving a 1999 Chevrolet Malibu northbound on the freeway, south of Nobel Drive, around 4:20 a.m. when the car drifted off the right side of the road and then swerved back to the left across all lanes, said CHP spokesman Brad Baehr.
The Malibu struck a steel guardrail in the center median, then came to rest facing south across two lanes of the 805, according to Baehr.
Moments later, the Malibu was sideswiped by a 2009 Chevrolet Cobalt just as the man in the Malibu was getting out of his vehicle, Baehr said.
The Malibu was then struck by a 2004 BMZ 325 and a large SUV, the officer said.
The man driving the Malibu was taken to Scripps La Jolla Hospital with major injuries to his legs and possible head trauma, Baehr said.
A 39-year-old San Diego woman who was driving the Cobalt was also taken to Scripps when she complained of chest pain.
A SigAlert for the area was lifted shortly before 7 a.m.
Authorities today announced that police have arrested a suspect in connection with Friday's sexual assault on the campus of San Diego Mesa College. The name of the suspect was not immediately released.
A 27-year-old man suffered fatal injuries as the result of a "punching game'' inside of a bar Saturday morning in the Gaslamp
neighborhood of San Diego.
Showers will be mostly light Saturday morning, decreasing into early Saturday afternoon. Another round of showers expected to push through late afternoon ending late Saturday night.
Police Chief David Nisleit Friday strongly disavowed what he described as an unofficial, "never authorized" departmental program that rewarded officers for making narcotics arrests.
On Friday, San Diego Police announced their search for a suspect involved in a robbery off the San Diego State University campus.
A court-appointed receiver has taken control of a Pacific Beach "hoarder house" that has accumulated trash, created unsafe conditions for children and harbored vermin in recent years, the San Diego City Attorney's Office announced Friday.
The owners of Hauser's Patio reached out to News 8 Friday morning asking to be put in contact with the couple who had their furniture stolen from their patio in Pacific Beach this week.
On Thursday night, the HeartCore Leadership company purchased thousands of dollars worth of Domino's Pizza to feed San Diego's homeless in downtown.