The man was driving a 1999 Chevrolet Malibu northbound on the freeway, south of Nobel Drive, around 4:20 a.m. when the car drifted off the right side of the road and then swerved back to the left across all lanes, said CHP spokesman Brad Baehr.
The Malibu struck a steel guardrail in the center median, then came to rest facing south across two lanes of the 805, according to Baehr.
Moments later, the Malibu was sideswiped by a 2009 Chevrolet Cobalt just as the man in the Malibu was getting out of his vehicle, Baehr said.
The Malibu was then struck by a 2004 BMZ 325 and a large SUV, the officer said.
The man driving the Malibu was taken to Scripps La Jolla Hospital with major injuries to his legs and possible head trauma, Baehr said.
A 39-year-old San Diego woman who was driving the Cobalt was also taken to Scripps when she complained of chest pain.
A SigAlert for the area was lifted shortly before 7 a.m.
Sunday was all about those who laid their lives on the line and with the number of veterans dwindling each year, many present at a Miramar ceremony hope to keep their memory alive.
A Navy Seal team member has died after his parachute failed to open during a Fleet Week demonstration over the Hudson River.
Metropolitan Transit System is scheduling extra service starting Monday for a three-day game series between the San Diego Padres and Chicago Cubs at Petco Park, a spokesperson said.
Veterans are being honored across San Diego County during Memorial Day weekend and dozens of Boy Scouts and Girl Scouts were among those spending their Saturday placing American flags at burial sites at the Fort Rosecrans National Cemetery.
Commencement was held Sunday for seniors at the University of San Diego, with ceremonies featuring a pair of distinguished alumni.
Cool and cloudy conditions start off Friday morning, but the sun will break through in the afternoon. Strong winds in San Diego County's deserts are also expected to ease up Friday morning.
A 30-year-old was knocked out and stabbed three times at the Beyer Trolley Station early Sunday morning, according to Officer Robert Heims of the San Diego Police Department.
A bird was responsible for an outage that left thousands without electricity Sunday, a San Diego Gas & Electric spokesperson said.
The remains of a U.S. Navy pilot killed when his plane was shot down during the Vietnam War have been brought to San Diego for burial.
In the wake of the Gate Fire, which ignited May 20, the Bureau of Land Management has issued new restrictions for Southern California counties, including San Diego.