The vote follows a bitter dispute that has seen Screen Actors Guild members fighting among themselves and left further behind than they started.
Ballots must be received by 5 p.m. (8 p.m. EDT) and will be counted shortly afterward.
Hollywood actors seem split on the deal, while those based in New York are largely in favor. The outcome could depend the vast majority of members who are mostly actors without work.
Either result would have little short-term effect, because actors have continued to work under their old, expired contract. But a rejection of the contract risks driving the union into irrelevance, as TV networks turn to a smaller actors union, AFTRA.
Copyright 2009 The Associated Press.
James asks 2-time NBA MVP Stephen Curry about his big weekend beating both the Los Angeles Clippers and Los Angeles Lakers, and the low-light of slipping on a fast break. When Stephen tries to shift blame on the ice beneath the court, Ron Funches wonders how that played into the subsequent airball.
Rep. Alexandria Ocasio-Cortez wants to debunk misleading representations of her proposed 70% marginal tax rate.
'Glass' star Sarah Paulson isn't part of the 80 million households that have streamed 'Bird Box.' Even though she's in it.
The cat's out of the bag! The new 'Spider-Man' trailer revealed the look of 'Sea Wall / A Life' star Jake Gyllenhaal's Mysterio.
'Star Trek: Discovery' star Sonequa Martin-Green weighs in on one of the key controversies surrounding her show.
'The Truths We Hold: An American Journey' author and Senator Kamala Harris makes a guarantee about Trump's border wall.
'Future Man' star Josh Hutcherson and his 'Hunger Games' co-stars had to give more than their IDs to get into Fetish Night at the Kit Kat Club.