LA JOLLA (CNS) - The Scripps Research Institute announced Monday the discovery of a molecule that helps retard the growth of certain types of cancer.
A TSRI study, published in the Proceedings of the National Academy of Sciences, found that a molecule called CBR-5884 inhibits the production of the amino acid serine by 30 percent.
Serine is a protein building block necessary for nucleotide, protein and lipid creation in all cells, and is part of the growth process of breast
cancer, lung cancer and melanoma, according to the TSRI researchers. They said CBR-5884 inhibits a specific enzyme known as 3-phosphoglycerate dehydrogenase, which is responsible for the first step in serine biosynthesis.
``In addition to discovering an inhibitor that targets cancer metabolism, we also now have a tool to help answer interesting questions about
serine metabolism,'' said Luke Lairson, an assistant professor of chemistry at TSRI.
The study also determined that the molecule didn't help with other types of cancer.
Lairson was assisted by scientists from the California Institute for Biomedical Research, Harvard University, the University of Michigan, Weill
Cornell Medical College of New York, Beth Israel Deaconess Medical Center of Boston and Katholieke Universiteit and Vlaams Instituut voor Biotechnologie, both of Belgium.
The research was funded by the National Institutes of Health, the Pancreatic Cancer Action Network in Manhattan Beach, the New York-based Damon Runyon Cancer Research Foundation and Los Angeles-based Concern Foundation.
San Diegans got a chance to hear from the Public Utilities Department about concerns about their soaring water bills Wednesday evening.
A 19-year-old San Diego man was behind bars Wednesday in connection with last summer's stabbing death of a well-liked transient in downtown Ocean Beach.
Due to inclement weather, the Warner Unified School District on Wednesday night announced its schools will be closed on Thursday, February 22.
A La Jolla physician was killed Wednesday when his private plane plunged into a Kearny Mesa construction site shortly after takeoff from Montgomery Field.
It's not often you look up into the sky and see something that blows your mind. In Wednesday's Zevely Zone, Jeff's goes to Moonlight Beach to meet the "Bubble Man."
Students at Eastlake Middle School have something to look forward to after the school launched “Outdoor Grill Meals” during lunch on Monday.
Ten lawsuits were filed Wednesday statewide - one of them in San Diego - by consumers who say they suffered burns when batteries in their e-cigarettes exploded.
After another very cold morning clouds will increase Wednesday afternoon. This will lead to a few light showers west of the mountains.
News 8 reporter Abbie Alford takes you bargain hunting! How do-it-yourselfers are refurbishing and sometimes reselling their great finds at the flea market.