LA JOLLA (CNS) - The Scripps Research Institute announced Monday the discovery of a molecule that helps retard the growth of certain types of cancer.
A TSRI study, published in the Proceedings of the National Academy of Sciences, found that a molecule called CBR-5884 inhibits the production of the amino acid serine by 30 percent.
Serine is a protein building block necessary for nucleotide, protein and lipid creation in all cells, and is part of the growth process of breast
cancer, lung cancer and melanoma, according to the TSRI researchers. They said CBR-5884 inhibits a specific enzyme known as 3-phosphoglycerate dehydrogenase, which is responsible for the first step in serine biosynthesis.
``In addition to discovering an inhibitor that targets cancer metabolism, we also now have a tool to help answer interesting questions about
serine metabolism,'' said Luke Lairson, an assistant professor of chemistry at TSRI.
The study also determined that the molecule didn't help with other types of cancer.
Lairson was assisted by scientists from the California Institute for Biomedical Research, Harvard University, the University of Michigan, Weill
Cornell Medical College of New York, Beth Israel Deaconess Medical Center of Boston and Katholieke Universiteit and Vlaams Instituut voor Biotechnologie, both of Belgium.
The research was funded by the National Institutes of Health, the Pancreatic Cancer Action Network in Manhattan Beach, the New York-based Damon Runyon Cancer Research Foundation and Los Angeles-based Concern Foundation.
News 8 spoke to the Golden State Killer's youngest victim on Wednesday following the announcement of an arrest in the case. Former Del Mar resident Margaret Wardlow was just 13 years old and living alone with her mother in Sacramento when she was raped by the man also known as the East Area Rapist.
An 11-year-old girl broke free from a would-be kidnapper Tuesday in Jamul, suffering a minor injury to an arm.
Police Thursday sought public help to find a 12-year- old boy who went missing from his school in Balboa Park near the San Diego Zoo.
About 130 Central Americans, mostly women and children, have arrived at the U.S. border with Mexico in a "caravan" of asylum-seeking immigrants that has drawn the fury of President Donald Trump.
As kids, some of us set up a lemonade stand to pull in a few extra bucks, but one Ocean Beach boy is not charging a dime for his lemonade. Instead, he is encouraging his customers to help him pay it forward.
UC San Diego Wednesday announced what the university touted as the largest private medicinal cannabis research donation in U.S. history.
People across San Diego County have noticed a disturbing trend as they have found, seemingly healthy, birds of prey dead.
If you have a cell phone, you've probably received a spam text. While they are annoying, experts say the texts can also lead to bigger problems.