LA JOLLA (CNS) - The Scripps Research Institute announced Monday the discovery of a molecule that helps retard the growth of certain types of cancer.
A TSRI study, published in the Proceedings of the National Academy of Sciences, found that a molecule called CBR-5884 inhibits the production of the amino acid serine by 30 percent.
Serine is a protein building block necessary for nucleotide, protein and lipid creation in all cells, and is part of the growth process of breast
cancer, lung cancer and melanoma, according to the TSRI researchers. They said CBR-5884 inhibits a specific enzyme known as 3-phosphoglycerate dehydrogenase, which is responsible for the first step in serine biosynthesis.
``In addition to discovering an inhibitor that targets cancer metabolism, we also now have a tool to help answer interesting questions about
serine metabolism,'' said Luke Lairson, an assistant professor of chemistry at TSRI.
The study also determined that the molecule didn't help with other types of cancer.
Lairson was assisted by scientists from the California Institute for Biomedical Research, Harvard University, the University of Michigan, Weill
Cornell Medical College of New York, Beth Israel Deaconess Medical Center of Boston and Katholieke Universiteit and Vlaams Instituut voor Biotechnologie, both of Belgium.
The research was funded by the National Institutes of Health, the Pancreatic Cancer Action Network in Manhattan Beach, the New York-based Damon Runyon Cancer Research Foundation and Los Angeles-based Concern Foundation.
A clear and warm weekend as temperatures begin to warm. Humidity levels in the desert will gradually lower through the weekend as a weak ridge briefly builds Saturday.
San Diegans and tourists alike headed to the coast to take in all that the first day of fall has to offer.
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San Diego Mayor Kevin Faulconer signed two resolutions with Tijuana Mayor Juan Manuel Gastelum supporting international trade and border infrastructure programs.
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