The 80-year-old Enberg made the announcement just before the Padres played the San Francisco Giants on Wednesday night. He has been with the Padres since 2010.
Enberg received the National Baseball Hall of Fame's Ford C. Frick Award this summer. He also has received the Rozelle Award from the Pro Football Hall of Fame and the Gowdy Award from the Naismith Memorial Basketball Hall of Fame.
Famed for his exclamation of "Oh my!" Enberg has been calling major league games in Southern California for nearly 20 seasons, split by stints as one of the most recognizable voices on NBC and CBS.
Enberg has cut back on his road schedule.
Copyright 2015 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.