The shooting occurred Friday night outside Brick by Brick on Elevation Street.
According to police, two men in their 20s got into a fight with two other people. One suspect took out a gun and shot both victims.
The suspects took off, police said, possibly in a Cadillac Escalade.
The victims were taken to local hospitals, where there was no word on their conditions.
Anyone with information about the shooting or the suspects is asked to call San Diego police.