The man, described only as in his 30s, was walking north across the 3200 block of Meade Avenue about 1:33 a.m. when he was hit by a vehicle traveling east, said San Diego police Officer Brad Ruff. Meade runs over Interstate 805.
The victim suffered massive head injuries and died at the scene, Ruff said.
Witnesses said the vehicle sped away and described it as a newer white hatchback.
The victim's name was withheld pending notification of his next of kin.