SAN DIEGO (CBS 8) - Two people are dead and four people are hospitalized after a wrong-way driver crashed head-on into another vehicle Saturday morning.

The crash happened at around 1:39 a.m. in the fast lane of NB SR-163, just north of I-8 near Mission Valley.

CHP investigators say a suspected DUI driver crashed his F-350 head-on into a Toyota Prius. The driver of the truck was arrested at the scene for DUI and taken to a nearby hospital.

The driver of the Toyota and the left rear passenger were pronounced dead on scene. Three other passengers were taken to local hospitals with moderate to critical injuries.